Spherical Aberration
A perfectly rotationally symmetric lens does not produce a perfect homogeneous field. The focusing strength varies with off-axis distance due to the lens geometry, such that higher-order aberrations grow rapidly. For a small ray angle θ, an ideal lens would focus an image at a radius $$
\Delta r_{image} = f\theta
$$ where f is the lens focal length. For a real lens, the focal length is approximated by
$$
\frac{1}{f_{\mathrm{eff}}} = \frac{1}{f}\left(1 + C_s \theta_0^2 + \cdots\right)
$$
Where $$
C_s
$$ is the spherical aberration coefficient. Hence the aberration-induced blur is
$$
\Delta r_{C,s} \approx C_s \theta^3
$$
For a practical system with θ=10 mrad and C_s=1 mm this already gives $$
\Delta r_{C,s} \approx 1
$$nm Compared to the electron wavelength (e.g. 2.5 pm at 200 kV) and the desired resolution this is a huge (400x) difference.
For comparison, this is reversed for a typical visible-light microscope, e.g. diffraction limited at 200 nm (high-NA oil immersion objective (NA ≈ 1.4) at green light (λ ≈ 550 nm)) with a smaller aberration blur in well-corrected lenses.